In T3640#96973, @Viacheslav wrote:

I think it will be enough to remove the peer and add again.
@hagbard what do you think?
https://github.com/vyos/vyos-1x/blob/d48dddab0509e562209adfb115b0e691b8e47f54/python/vyos/ifconfig/wireguard.py#L197

Wireguard has no link states on the interface, the ip command just does an 'administrative' up down, which won't start a renegotiation. The policy description (remove peer) needs to be removed from the wg interface and re-added, otherwise you need to wait until wg tries to rekey which will then eventually renegotiate the entire connection.
The removal was as far as I recall part of the original vyos code, so it may have been removed at one point, I haven't looked into the code yet.